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KMID : 1141320210360020206
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Kosin Medical Journal
2021 Volume.36 No. 2 p.206 ~ p.210
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Predominant Myofibrillar Pathology with Preserved Sarcolemmal Aquaporin 4 Immunoreactivity in a Patient with Neuromyelitis Optica-Associated HyperCKemia
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Huh So-Young
Shin Jin-Hong
Park Yeong-Eun
Kim Ho-Jin
Kim Dae-Seong
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Abstract
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A 49-year-old man developed recurrent myalgia and hyperCKemia during acute attacks of neuromyelitis optica. Muscle biopsy was performed, and the pathological findings were analyzed. Predominant myofibrillar pathology was observed, which constitutes a unique finding that has not been reported before. This case result shows that neuromyelitis optica-associated hyperCKemia can produce variable pathologic phenotypes. Further studies are needed to elucidate the relationship between myofibril destruction and aquaporin 4 autoimmunity.
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KEYWORD
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Anti-aquaporin 4 autoantibody, Myopathy, Neuromyelitis optica
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